CTNS was also shown to be closely related to markers of some immune cells, including M2 macrophage, dendritic cells, Th1, Th2, Tfh, Th17; Treg SHMT1 for CD8+T, B cell, M1 macrophage, neutrophils, Th2, Tfh, Th17, Treg, T cell exhaustion; SLC38A7 for T cell (general), monocyte, tumor associated macrophages (TAM), M2 macrophage, neutrophils, Th2, Tfh, Th17, Treg; Insertion of HPRT1, CTNS, SHMT1 and SLC38A7 and markers TAM (CD68), dendritic cells (BDCA-1), Th2 (STAT6, GATA3), Tfh (BCL6), Treg (STAT5B, TGFb) (Supplementary Table 5). This evidence concerns the gene SHMT1 and neoplasm.