As shown in Supplementary Table 4, the adjusted results based on tumor purity revealed a significant correlation between HPRT1 and monocyte markers (CD8B), T cell (general) (CD3D), B cell (CD19, CD79A, CD68), macrophage M1 (NOS2, IRF5, CCR7, KIR2DS4), dendritic cells (HLA-DPB1, BDCA-1, BDCA-4), Th2 (GATA3, STAT6), Tfh (BCL6, STAT5B, TGFb) in 520 HNSCC samples. This evidence concerns the gene NOS2 and head and neck squamous cell carcinoma.