AKT1 and oral cavity squamous cell carcinoma: Patients with oral squamous cell carcinoma (OSCC) with high levels of HPRT1 had a worse prognosis (40), and both in vitro and in vivo experiments revealed that HPRT1 overexpression improved the resistance of patients with OSCC to cisplatin by activating the MMP1/PI3K/Akt axis (41).