CHRNA3 and chronic obstructive pulmonary disease: We identified a nominally statistical association between CHRNA3 rs1051730 and COPD risk under the allelic and dominant models in all populations (allelic model: OR = 1.630, 95% CI = 1.293–2.054, p < 0.001; dominant model: OR = 1.662, 95% CI = 1.300–2.124, p < 0.001), a nominally significant association under the allelic and dominant models in Asians (allelic model: OR = 1.591, 95% CI = 1.204–2.103, p = 0.001; dominant model: OR = 1.625, 95% CI = 1.222–2.160, p = 0.001), and a null association under all three models in Caucasians.