Of these, eight SNPs were statistically associated with the risk of LC or COPD risk; three SNPs were nominally statistically related to COPD risk (rs1051730 and rs6495309 in CHRNA3 and rs16969968 in CHRNA5); and eight SNPs were nominally statistically associated with LC risk (rs1051730, rs12914385, rs578776, rs6495309, rs8042374, and rs938682 in CHRNA3 and rs16969968 and rs588765 in CHRNA5). Here, CHRNA3 is linked to chronic obstructive pulmonary disease.