CHRNA5 and chronic obstructive pulmonary disease: Of these, eight SNPs were statistically associated with the risk of LC or COPD risk; three SNPs were nominally statistically related to COPD risk (rs1051730 and rs6495309 in CHRNA3 and rs16969968 in CHRNA5); and eight SNPs were nominally statistically associated with LC risk (rs1051730, rs12914385, rs578776, rs6495309, rs8042374, and rs938682 in CHRNA3 and rs16969968 and rs588765 in CHRNA5).