The expression of CXCL2 was significantly associated with favorable OS (HR = 0.61, 95% CI = 0.43–0.86, P = 0.0046), PFS (HR = 0.66, 95% CI = 0.48–0.90, P = 0.0083), and DSS (HR = 0.45, 95% CI = 0.29–0.71, P = 0.00045), which was consistent with low expression of CXCL2 in HCC tissues. The gene discussed is CXCL2; the disease is hepatocellular carcinoma.