CXCL2 and neoplasm: Figure 3H showed the expression pattern of CXCL2 across diverse TCGA cancer types, and low expression of CXCL2 was associated with malignancy clinical features, such as tumor grade, stage, and nodal metastasis (Figures 3I–K). Finally, the low expression of CXCL2 in two HCC cell lines, Huh7 and MHCC97H, was further confirmed by real-time PCR and western blotting, compared with the normal hepatocyte cell line HHL-5 (Figures 3L, M).