It was found that mTOR signal pathway and HIF-1 signal pathway were activated in PLOD2 up-regulated group, which played important role in the process of angiogenesis, at the same time, extracellular structure organization pathway, extracellular matrix organization pathway and collagen fibril organization pathway were also activated, which was consistent with the malignant behavior of cancer metastasis (Figures 4C, D). This evidence concerns the gene PLOD2 and cancer.