On the other hand, it has been illustrated that the overexpression of PD-1 and PD-L1 on the cervical DCs and T lymphocytes is correlated to greater cytological abnormalities and high-risk HPV positivity in individuals with CIN as well as a poor prognosis in cervical cancer patients (72). The gene discussed is CD274; the disease is cervical squamous intraepithelial neoplasia.