Translocation of TFE3 and expression of TFE3 proteins can be identified in different types of tumors, such as Xp11.2 translocation renal cell carcinoma (RCC), epithelioid haemangioendothelioma, alveolar soft part sarcoma, perivascular epithelioid cell tumor, ossifying fibromyxoid tumor, and malignant chondroid syringoma (2). The gene discussed is TFE3; the disease is hereditary clear cell renal cell carcinoma.