In the present study, it was found that the probability of lymph node and distant metastasis in the TFE3-positive RCC were 10.9% (10 out of 91 patients) and 6.6% (6 out of 91), respectively, whereas the patient in the TFE3-negative RCC were 1.3% (9 out of 705 patients) and 0.9% (6 out of 105 patients), respectively. Here, TFE3 is linked to renal cell carcinoma.