Colony formation experiments also showed that increasing the level of SMS expression can increase the number of clones, whereas reducing SMS expression can inhibit the formation of clones (Figures 2E–H).The results of the wound-healing experiment showed that over-expression of SMS can promote the migration of pancreatic cancer cells while knocking down SMS significantly inhibited the migration rate (Figures 2I–L). This evidence concerns the gene SMS and pancreatic neoplasm.