The second classification concerns the availability of tumor antigen due to a high tumor mutational burden or microsatellite instability and checkpoint expression on activated, antigen-exposed immune cells, along with programmed death-ligand 1 (PD-L1) on tumor cells, which can be “high” (positive) or “low” (negative) indicative of the probability of response to ImT (1). Here, CD274 is linked to neoplasm.