These include: a) the repopulation after day 21 of resting/resistant phenotypic cells, accelerating the proliferation of cancer cells (4); b) vascular rebound due to VEGF/placental growth factor (PIGF)-initiated angiogenesis and the triggering of vasculogenesis (a form of VEGF-independent angiogenesis) due to the influx of endothelial progenitor cells from the bone marrow (16) (bone marrow-derived precursor endothelial cells, BMDCs); c) the recruitment of MDSCs inhibiting the activity of CD8+ T cells and DCs. The gene discussed is CD8A; the disease is cancer.