This study was conducted in order to elucidate the role of IQGAP in mouse hepatic cancer progression and its relation with pro-apoptotic and antiapoptotic genes, such as the TNF-related apoptosis-inducing ligand (TRAIL) family genes, BAX, Bcl-2, caspase-3 and -9, IL-8, and CXC3, and other factors. This evidence concerns the gene CASP3 and liver cancer.