IL6R and neoplasm: Most of the up-regulated genes are located on chromosome 1q, such as CKS1B, PSMD4, IL6R, ADAR, MCL1, etc. in tumor proliferation, among which CKS1B acts as gene encoding a cofactor for the Skp2-dependent ubiquitination of p27kip1 (24), which negatively regulates the G1/S transition of the cell cycle, thereby promoting cell proliferation and leading to disease progression (25).