These data identified the downregulated plasma exosomal lncRNAs (LINC00265, LINC00467, and UCA1) and the upregulated plasma exosomal lncRNA (SNHG1) in AML patients in comparison with HD, and showed that the dysregulations of these exosomal lncRNAs also exist in the patients with specific FAB subtypes. This evidence concerns the gene UCA1 and Huntington disease.