Combination of Y15 and chemotherapeutic agents efficiently reverse the chemo-resistance and exhibited strengthened cytotoxicity to tumor cells cultured on 2D collagen gels containing laminin (Figures 5C, D), suggesting that blockade of ntegrin/FAK/YAP/TAZ signals by Y15 could suppress the pro-tumor effects induced by laminin. Here, PTK2 is linked to neoplasm.