Furthermore, we found that Y15 suppressed the pro-tumor effects induced by laminin and YAP/TAZ, as evidenced by the weakened cell proliferation (Figure 4D), colony formation (Figure 4E) and invasion capability (Figure 4F) in 2D collagen gels (containing laminin) cultured A549 and NCI-H1299 cells. Here, LAMB2 is linked to neoplasm.