Meanwhile, 2D collagen gels (containing laminin) cultured A549 and NCI-H1299 cells revealed weakened capability of colony formation (Figure 2H) and invasion (Figure 2I) when inhibiting integrin α6 and β4, indicating that laminin facilitated NSCLC cells proliferation through integrin α6β4. The gene discussed is LAMB2; the disease is non-small cell lung carcinoma.