GPIIb/IIIa (also known as integrin αIIbβ3) expressed by platelet could bind to αγβ3 integrin expressed by tumor cells (47) and make αγβ3 active, which could stimulate the NF-κB pathway for epithelial–mesenchymal transition (EMT; an invasive phenotype in tumor cells) activation and induce matrix metalloproteinase (MMP) upregulation for tumor cell invasion (13, 46, 48). Here, ITGA2B is linked to neoplasm.