Higher age was associated with discordant PD-L1 TPS regarding the 1% cutoff (pWilcoxon ranked sum = 0.023; Supplementary Fig. 4), and patients with no shared genetic alterations between the primary lung carcinoma and the BM were all discordant regarding the 50% cutoff (pFisher’s exact < 0.001; Supplementary Table 3). This evidence concerns the gene CD274 and lung carcinoma.