Since 60% of the oxygen consumption of kidneys is devoted to sodium reabsorption in proximal tubules to fulfill the high metabolic energy demand [44], high expression of GPX4 may act as an essential antioxidant force against massive ROS production in proximal tubular cells of DKD patients and defect antioxidant capacity in kidneys is a hallmark of DKD. This evidence concerns the gene GPX4 and diabetic kidney disease.