Taken together, our identified rs200713361 − F3 − hsa − miR − 20 − 5p/hsa − miR − 93 − 5p − AGE − RAGE signaling pathway may have significant roles in the pathogenesis of AAA and even some diseases with similar pathology (such as thoracic aortic aneurysm), which merits future investigation and extrapolation. The gene discussed is RENBP; the disease is thoracic aortic aneurysm.