In the study by Zhou et al., WB displayed a faster postoperative downward trend of GPX4 in IRI mice compared to UUO mice, and it was still not restored at postoperative day 28 [121], suggesting that ferroptosis occurs slowly in the context of CKD (iron deposition and lipid peroxidation take longer), and also that the altered hemodynamic rhythm serves as a worsening factor for GPX4 depletion. This evidence concerns the gene GPX4 and chronic kidney disease.