GPX4 and chronic kidney disease: In a 5/6 nephrectomy-induced CKD rat model, downregulation of GPX4 and SLC7A11, and upregulation of ACSL4 and specific mitochondrial changes were observed together with renal iron accumulation, oxidative stress, and lipid peroxidation in rats at week 8 postoperatively, and residual kidney iron metabolism disorders (FPN downregulation and NCOA4 upregulation) was an important mechanism for ferroptogenesis [33].