• Bone Marrow Biopsy: unremarkable • PET: unremarkable • CT-scan thorax and abdomen: pleural effusions and lobar pneumonia • Hb: 9.5 g/dL • WBC 2270 /μL • Plts 105 × 103/μL. • sCr: 4.65 mg/dL • ESR: 45 mm/h, • CRP: 16.4 mg/dL • Ferritin: 2,500 ng/mL • C3/C4 within normal range • ANA, ANCA: negative • Bronchoscopy and Bronchoalveolar Lavage: positive for Pneumocysistis Carinii e per Herpes Simplex. This evidence concerns the gene C3 and Pleural effusion.