In tumor patients with a relatively high level of neutrophils, T cell immune response is often reduced, as represented by the reduced expression of cytotoxic T cell genes including CD8A, CD8B, GZMA, and GZMB, the reduced number of CD3 + CD8 + cells, and the reduced expression of IFN-γ related genes (22). The gene discussed is GZMA; the disease is neoplasm.