HAVCR2 and neoplasm: In addition, WT ARI-0001 and TCRKO ARI-0001 CAR-T cells shared a comparable expression of LAG3 and TIM3 exhaustion markers after tumor cells killing (Figure 3I) as well as similar production of interferon (IFN)-γ and tumor necrosis factor (TNF)-α (Figures 3J, K).