Supporting insights also included that the expression levels of MHC molecules, costimulatory molecules, and adhesion molecules in high-MDH-score HCC patients were comprehensively elevated (Figures 6A, S6D), and the MDH score was positively correlated with the expression levels of PD1, CD80 and CD86 (Figure 6A). Here, HLA-C is linked to hepatocellular carcinoma.