Interestingly, the upregulated genes in subtype 1 were dramatically associated with tumour metabolism, including metabolic pathways and drug metabolism (Figure S2B), while tumour-associated signalling pathways, such as ECM receptor interaction, focal adhesion, the NFKB signalling pathway and the TNF signalling pathway, were markedly downregulated (Figure S2C). Here, NFKB1 is linked to neoplasm.