Conversely, the upregulated genes in subtype 3 were dramatically involved in tumour-associated signalling pathways, including the cell cycle, ECM receptor interaction, P53 signalling pathways, pathways in cancer, PI3K/AKT signalling pathways, focal adhesion and DNA replication (Figure S2B), while tumour metabolism in subtype 3 was remarkably suppressed (Figure S2C). Here, TP53 is linked to cancer.