The GSVA further implied that P53 signalling, ROS signalling, oxidative phosphorylation, glycolysis, IL2/STAT5 signalling, and DNA repair were remarkably activated in HCC with high MDH scores, while KRAS signalling, angiogenesis, adipogenesis and fatty acid metabolism were inhibited (Figure 5F). This evidence concerns the gene IL2 and hepatocellular carcinoma.