Interestingly, the upregulated genes in subtype 1 were dramatically associated with tumour metabolism, including metabolic pathways and drug metabolism (Figure S2B), while tumour-associated signalling pathways, such as ECM receptor interaction, focal adhesion, the NFKB signalling pathway and the TNF signalling pathway, were markedly downregulated (Figure S2C). This evidence concerns the gene TNF and neoplasm.