Additionally, CAFs directly inhibits the activity of cytotoxic lymphocytes by killing CD8+T cells in an antigen-dependent manner via PD-L2 and FASL (50) and increasing the synthesis of matrix components such as hyaluronan Q16 (14, 15) and change the T cell role in the TME to one that promotes tumor growth (15). This evidence concerns the gene PDCD1LG2 and neoplasm.