NLRP3 and brain ischemia: The study found that down-regulation of miRNA-20b expression can inhibit the nucleotide binding oligomerization domain like receptor protein 3 (NLRP3) signaling pathway, reduce the IL-1β, IL-18 levels, adenosine triphosphate and reactive oxygen species during cerebral ischemia, thereby reducing the inflammatory injury after ischemic stroke (84).