Therefore, SNHG8, as an endogenous competitive RNA, adsorbs miR-425-5p to regulate SIRTI/NF-KB to reduce the inflammatory response of cerebral microvascular endothelial cells and microglia induced by cerebral ischemia/reperfusion, and protect the blood brain barrier of MCAO/R mice (45). The gene discussed is NFKB1; the disease is brain ischemia.