Notably, BRD4 is upregulated in PA SMCs of PAH patients and in lungs or distal PAs of rat PH models, and is posttranscriptionally regulated by microRNA-204 (87), which is concomitantly involved in PA calcification (55), providing for an additional epigenetic link between inflammation and vascular calcification. The gene discussed is BRD4; the disease is pulmonary arterial hypertension.