Hypertension-induced aortic stiffeningPositive correlation between IL-6 and aortic stiffness (89)Arterial stiffening in chronic kidney disease (CKD)IL-6 levels in patient plasma are positively correlated to arterial wall stiffness (90).Vascular remodeling in PHIL-6 promotes SMC proliferation and migration in PH, leading to medial wall thickening in distal PAs (60). IL-6 upregulates MMP-expression in PH, promoting ECM remodeling (60).IL-6 depletion attenuates lung vascular remodeling in a rat MCT model of PH (8). The gene discussed is IL6; the disease is hypertensive disorder.