TLR5 and posterior cortical atrophy: identified several androgen-responsive elements in the promoter of CXCR4 and CXCR7, and the CXCL12/CXCR4 and CXCL12/CXCR7 axes may be regulated by the AR signaling pathway and TLR5 ligand (flagellin) in PCa (43), implying the potential relationship between chemokines and ADT response.