The CXCR7/RDC1 axis was identified as the downstream of the CXCL12/CXCR4 axis, which was associated with the aggressiveness of PCa (14), and antibody against CXCL12 inhibited the proliferation of LNCaP C4-2B and PC3 cells (15), implying the potential therapeutic value of the CXCL12/CXCR4 axis in PCa. Here, ACKR3 is linked to posterior cortical atrophy.