identified several androgen-responsive elements in the promoter of CXCR4 and CXCR7, and the CXCL12/CXCR4 and CXCL12/CXCR7 axes may be regulated by the AR signaling pathway and TLR5 ligand (flagellin) in PCa (43), implying the potential relationship between chemokines and ADT response. This evidence concerns the gene CXCL12 and posterior cortical atrophy.