Among them, 13 genes (ACTN3, HIF1A, MRS2, PARK7, PNKD, SLC25A12, TP53, LDHA, LDHB, SLC16A3, SLC16A7, SLC16A8, and SLC5A12) were upregulated in tumor tissues, whereas 6 genes (HAGH, PER2, PFKFB2, LDHAL6A, LDHD, and SLC5A8) were upregulated in normal tissues (Figure 1A). The gene discussed is PNKD; the disease is neoplasm.