After minimizing the potential risk of overfitting, we established nine ferroptosis-related genes associated with CLL prognosis: AKR1C3, BECN1, CAV1, CDKN2A, CXCL2, JDP2, SIRT1, SLC1A5, and SP1. The gene discussed is AKR1C3; the disease is B-cell chronic lymphocytic leukemia.