In univariate analysis, FPS high risk (P=0.001), Binet stage B or C (P=0.038), B symptoms (P=0.045), age>65 years (P=0.047), hemoglobin<100 g/L (P=0.002), β2-MG>3.5 mg/L (P=0.011), TP53 disruption (P=0.032), IGHV unmutated (P=0.001), and CLL International Prognosis Index (CLL-IPI) (P<0.001) were significantly correlated with inferior OS (Figure 6A). The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.