High expression of miR-1246 in hypoxic glioma-derived exosomes (H-GDES) significantly induces the M2-type polarization of macrophages to activate the STAT3 signaling while inhibiting the NF-κB signaling pathway, which subsequently promotes glioma proliferation, migration, and invasion both in vitro and in vivo (109). Here, STAT3 is linked to glioma.