TP53 and central nervous system cancer: Further, the top 50 genes which negatively and positively correlated with TP53I13 were identified and analyzed to understand the molecular mechanisms associated with TP53I13. PPI analysis revealed that significant correlation betweenTP53 and TP53I13. A previous study reported that TP53 mutations and polymorphisms are frequently reported in glioma patients, which is the primary risk factor in gliomas (36).