Detection of DEspR+CD66b+ neutrophils, with differential cellular localization in healthy volunteer BALF 24h after segmental-LPS challenge is concordant with previous studies showing a] DEspR+CD11b+MPO+ neutrophils in intra-alveolar exudates with cell membrane, cytoplasmic and nuclear expression in postmortem lung tissue sections from ARDS patients (23), and DEspR+ tumor cells (31). This evidence concerns the gene ITGAM and acute respiratory distress syndrome.