Supplementary Figures 5C, D shows that in addition to CD56bright NK cells, CD56dim subset are also important cytokine-producing cells in COVID-19 patients. Furthermore, as shown in a representative flow cytometric staining (Figure 3C), a large proportion of NK cells of ICU patients were double-positive for IFN-γ and TNF-α. The gene discussed is IFNG; the disease is COVID-19.