Since we have previously reported in various primary and immortalized cells that (1) UCP2 expression is involved in the modulation of cell proliferation through metabolic rewiring (17, 18), and (2) the glutamine pool directly controlled UCP2 translation (27, 28), we investigated how UCP2 might be involved in the glutamine sensing response in T-ALL cells through metabolic challenge. Here, UCP2 is linked to acute lymphoblastic leukemia.