A recent study revealed that chronic psychological stress upregulated the levels of neutrophil chemokines (CXCL1 and CXCL2) which stimulated neutrophil mobilization and infiltration into colonic tissues, thereby secreted excessive proinflammatory cytokines (IL-1β, IL-6, IL-17A, and IL-22), so the robust inflammatory response aggravating colitis in a DSS-induced mice model (80). Here, IL6 is linked to colitis.