Finally, we investigated the efficacy of our B7-H3-targeting mAbs in comparative analyses of 8H8_SDIE versus 8H8_WT and respective controls to induce NK reactivity against sarcoma cells derived from patients diagnosed with liposarcoma, chondrosarcoma, rhabdomyosarcoma, osteosarcoma or synovial sarcoma. This evidence concerns the gene CD276 and osteosarcoma.