Flow cytometry analysis of CD107a expression revealed that presence of 8H8_WT in cocultures with sarcoma cells RD-ES, SaOs and SW1353 already significantly enhanced CD107a expression, and a significantly more pronounced effect was observed for all cell lines upon treatment with 8H8_SDIE, whereas control mAbs had no relevant effect (Figure 3C). The gene discussed is LAMP1; the disease is sarcoma.