KCNN4 and rheumatoid arthritis: Notably, inhibition of the KCa3.1 channel also upregulated MMP1 mRNA and enhanced secretion of IL-1β while decreasing that of IL1-RA, resulting in inhibition of short-term activation of Th2 lymphocytes in RA and consequently, a shift in the inflammatory homeostasis of RA to a pro-inflammatory state (41).