The traditional drug of RA ranges from disease-modifying anti-rheumatic drugs (DMARDs) (eg, methotrexate and Janus kinase inhibitor tofacitinib) to biologic agents (eg, tumor necrosis factor inhibitors) and some adjuvant therapy drugs like non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids (GC) (1). The gene discussed is TNF; the disease is rheumatoid arthritis.