The genes populated pathways directly required for the generation of anti-TB immune responses such as NFkB, M1 polarization, ERK/MAPK, and Type I IFN signaling, as well as those pathways that play a role in conditioning cellular or humoral processes indirectly involved in the fine-tuning of immune responses, e.g. Cell adhesion, Calcium Signaling/Transport, Apoptosis, NADPH oxidase, Cell Migration, Cell Proliferation and Antiviral etc., (Table 4). The gene discussed is NFKB1; the disease is tuberculosis.