In fact, to the best of our knowledge, for the first time in an allergic dermatitis model, we demonstrate that HA signaling via H4R expressed in DCs induces an inflammatory response associated with the activation of Th2 effector lymphocytes, and also non-conventional CD8 Tc2 lymphocytes that are associated with the severity of the pathology (38), as specific antibodies and effector recruitment are increased. This evidence concerns the gene CD8A and atopic eczema.