A lower degree of infiltration of PD-L1+CD68+ cells was seen in both tumor and stroma in the Io+Chemo over in the Chemo (density: tumor, P = 0.0462, stroma, P = 0.0147, total, P = 0.0248; percentage: tumor, P = 0.0537, stroma, P =0.0171, total, P = 0.0156; Figure 3C). This evidence concerns the gene CD68 and neoplasm.