Nonetheless, higher levels of CD8+ eff/m with an exhausted (CD45RA- CD45RO+ HLA-DR+ CD38+ Tigit+ PD1++) phenotype in patients with AML relapse present only in the last time point post DLI, are pointing towards the importance of functional CD8+ eff/m for a long-lasting effective DLI response. The gene discussed is CD38; the disease is acute myeloid leukemia.