Our previous studies showed that CYP27A1 gene rs17470271 T; rs933994 T allele frequencies were respectively significantly related to leukopenia, drug resistance, and lncRNA NEAT1 gene rs3825071 TT genotype; T allele frequencies were significantly increased in sputum smear-positive PTB patients (24, 36). The gene discussed is CYP27A1; the disease is Decreased total leukocyte count.