CCNB1 and neoplasm: Interestingly, a recent study showed that IL-33 can inhibit cyclin C (CCNC, G0/G1 transition) and cyclin B1 (CCNB1, G2/M transition) and that cysteine aspartase-3 (CASP3) activation decreases tumor cell proliferation and thus may be involved in cell proliferation in an environment- and cell type-dependent manner (72).