TLR4 and gastric cancer: In addition, another study showed that the HMGB1/TLR4/MyD88 signaling pathway promotes GC progression and that silencing HMGB1/TLR4/MyD88 signaling in GC cells with HMGB1 siRNA significantly inhibits GC cell proliferation, migration and invasion and induces apoptosis via the NF-κB pathway (86).