DHX58 and viral infectious disease: Considering the immune related gene expression patterns of fish after virus infection, previous study illustrated that IκBα-like protein A(IκBαLA) coding gene was down-regulated in RLR, mitogen-activated protein kinase (MAPK), Toll-like receptor (TLR), T cell receptor (TCR), B cell receptor (BCR), NF-κB signal pathways in grass carp (Ctenopharyngodon idella) after Grass Carp Reovirus (GCRV) infection (38).