NLRP3 and CINCA syndrome: It is yet unclear why cold precipitates the attacks in FCAS, but a recent study showed that NLRP3 mutants (FCAS-associated NM_001243133.2(NLRP3):c.1058T>C,p.(Leu353Pro) and - c.1687T>A, p.Tyr563Asn, as well as CINCA/NOMID-associated NM_001243133.2(NLRP3):c.907G>A; p.(Asp303Asn) and - c.1709A>G, p.Tyr570Cys) formed cryo-sensitive, calcium-dependent molecular aggregates that could trigger inflammasome assembly, activation, and subsequent pro-inflammatory cytokine release (97).