To further explore the mechanisms involved in CAPS pathogenesis, engineered mutations causing FCAS and MWS have been assessed into mouse model by Brydges et al.; being Ala352 (c.1055C>T; p.Ala352Val) and Leu353 (c.1058T>C; p.Leu353Pro) residues (Ala350 and Leu351 in mouse NLRP3) highly conserved both in mouse and in human, Nlrp3A350VneoR/+ and Nlrp3L351PneoR/+ mice have been created. This evidence concerns the gene NLRP3 and cryopyrin-associated periodic syndrome.