To investigate the role of ALDH1A3 in CRC, we examined the mRNA level of ALDH1A3 in six CRC cell lines (SW480, HCT116, LS174T, DLD-1, HCT15, and SW620), and found that ALDH1A3 was highest expressed in SW480 cells, which was used in further studies (Figure 2(a)). This evidence concerns the gene ALDH1A3 and colorectal carcinoma.