NRAD1 and colorectal carcinoma: Our previous study indicated that Linc00284 plays an important role in CRC progression [12], qPCR analysis showed that knockdown of ALDH1A3 significantly reduced the expression level of Linc00284 (Figure 3(a)), while overexpression of ALDH1A3 upregulated Linc00284 expression markedly (Figure 3(b)).