Similarly, the TRAIL-induced apoptosis pathway which kills diseased cells such as tumor cells or virus-infected cells can be mediated by PACS-2, where dephosphorylation of PACS-2 triggered by TRAIL promotes their recruitment and translocation of Bid to mitochondria with the subsequent cyt-c release (Aslan et al., 2009). Here, PACS2 is linked to neoplasm.