WEE1 and familial pancreatic carcinoma: - highly effective ATP-competitive inhibitor of CK1δ (IC50 CK1δ=4 nM, IC50 CK1ε=25 nM)- highly selective towards CK1δ when tested against more than 321 protein kinases- high efficiency against p38α MAPK with an IC50 value three-fold higher compared to CK1δ- inhibitory effect on human pancreatic cancer cell lines Colo357 and Panc89 (EC50 of 3.5 and 1.5 μM, respectively)