- antioxidant and anti-inflammatory activities- potent inhibition of all CK2 isoforms with IC50 values below 1 μM- affects ROS-producing enzymes and protects neurons from oxidative stress-induced damage- potential up- and/or down-regulation of cytokines via Nrf2, ERK1/2, PI3K/Akt, JNK, MAPK pathways- Improvement of cognitive performance and cognitive functions in patients with neurological diseases or neurobehavioral disorders- inhibition of Aβ production in vitro and protection against cognitive impairments in a mouse model. The gene discussed is MAPK8; the disease is Cognitive impairment.