These two central regulators of redox homeostasis in plants control detoxification enzymes, such as the catalase CAT2 (Prupe_5G011300, ortholog) and can induce expression of WRKY53 (Prupe_5G117000, ortholog) (Pitzschke et al., 2009), a transcription factor responding to infection or abiotic stress (Hu et al., 2012). The gene discussed is CAT; the disease is infection.