The relative frequency of BRAF mutations varied greatly across the different cancer types (Fig. 2A): in thyroid cancer 39.53% (742/1,877) of the samples contained a reoccurring BRAF mutation, in melanoma 32.91% (1,809/5,496) of the samples contained a BRAF mutation, in colorectal cancer 10.38% (1,337/12,880) contained a BRAF mutation and in NSCLC 4.4% (850/19,319) contained a BRAF mutation. Here, BRAF is linked to melanoma.