In lung cancer, the interaction of IQGAP3 with DNA repair protein Rad17 was essential for Rad17 expression and foci formation, the Mre11-Nbs1-Rad50 complex formation, and ATM/Chk2 and ATR/Chk1 pathways activation (Zeng et al., 2020). The gene discussed is CHEK1; the disease is lung cancer.