While contrasting levels of LysoTracker and Rab7 expression were shown between MAP K10-GFP infected MDMs from JD+ subclinical and JD+ clinical cows, it is important to note that infection with pathogenic mycobacterial species has shown that acquisition of Rab7 is not always an indicator of a phagosome’s progression to acidification and destruction of its contents, as these bacteria can interrupt signaling and binding of effectors downstream from Rab7 (Clemens et al., 2000b; Sun et al., 2007; Keown et al., 2012). Here, KRT10 is linked to infection.